Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1

BACKGROUND: Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patient survival which highlights this heterogeneity. However, only limited DNA meth...

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Main Authors: Morenos, Leah, Chatterton, Zac, Ng, Jane L, Halemba, Minhee S, Parkinson-Bates, Mandy, Mechinaud, Francoise, Elwood, Ngaire, Saffery, Richard, Wong, Nicholas C
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050407/
https://ncbi.nlm.nih.gov/pubmed/24885794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-123
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