Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance

BACKGROUND: Patient-derived tumour xenografts are an attractive model for preclinical testing of anti-cancer drugs. Insights into tumour biology and biomarkers predictive of responses to chemotherapeutic drugs can also be gained from investigating xenograft models. As a first step towards examining...

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Detalhes bibliográficos
Main Authors: Wong, Nicholas C, Bhadri, Vivek A, Maksimovic, Jovana, Parkinson-Bates, Mandy, Ng, Jane, Craig, Jeff M, Saffery, Richard, Lock, Richard B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057609/
https://ncbi.nlm.nih.gov/pubmed/24885906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-416
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