Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1

BACKGROUND: Acute Myeloid Leukaemia (AML) is a highly heterogeneous disease. Studies in adult AML have identified epigenetic changes, specifically DNA methylation, associated with leukaemia subtype, age of onset and patient survival which highlights this heterogeneity. However, only limited DNA meth...

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Detalhes bibliográficos
Main Authors: Morenos, Leah, Chatterton, Zac, Ng, Jane L, Halemba, Minhee S, Parkinson-Bates, Mandy, Mechinaud, Francoise, Elwood, Ngaire, Saffery, Richard, Wong, Nicholas C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050407/
https://ncbi.nlm.nih.gov/pubmed/24885794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-123
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