PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

We determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with clinically relevant chemotherapies to kill medulloblastoma cells. In medulloblastoma cells PDE5 inhibitors interacted in a greater than additive fashion with vincristine/etoposide/cisplatin to cause cell...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Roberts, Jane L, Booth, Laurence, Conley, Adam, Cruickshanks, Nichola, Malkin, Mark, Kukreja, Rakesh C, Grant, Steven, Poklepovic, Andrew, Dent, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Landes Bioscience 2014
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049791/
https://ncbi.nlm.nih.gov/pubmed/24651037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28553
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