Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: insights into mitochondrial–nuclear interactions

Age-related macular degeneration (AMD) is the leading cause of vision loss in developed countries. While linked to genetic polymorphisms in the complement pathway, there are many individuals with high risk alleles that do not develop AMD, suggesting that other ‘modifiers’ may be involved. Mitochondr...

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Autori principali: Cristina Kenney, M., Chwa, Marilyn, Atilano, Shari R., Falatoonzadeh, Payam, Ramirez, Claudio, Malik, Deepika, Tarek, Mohamed, Cáceres-del-Carpio, Javier, Nesburn, Anthony B., Boyer, David S., Kuppermann, Baruch D., Vawter, Marquis, Michal Jazwinski, S., Miceli, Michael, Wallace, Douglas C., Udar, Nitin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049308/
https://ncbi.nlm.nih.gov/pubmed/24584571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu065
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