Human Retinal Transmitochondrial Cybrids with J or H mtDNA Haplogroups Respond Differently to Ultraviolet Radiation: Implications for Retinal Diseases

BACKGROUND: It has been recognized that cells do not respond equally to ultraviolet (UV) radiation but it is not clear whether this is due to genetic, biochemical or structural differences of the cells. We have a novel cybrid (cytoplasmic hybrids) model that allows us to analyze the contribution of...

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Main Authors: Malik, Deepika, Hsu, Tiffany, Falatoonzadeh, Payam, Cáceres-del-Carpio, Javier, Tarek, Mohamed, Chwa, Marilyn, Atilano, Shari R., Ramirez, Claudio, Nesburn, Anthony B., Boyer, David S., Kuppermann, Baruch D., Jazwinski, S. Michal, Miceli, Michael V., Wallace, Douglas C., Udar, Nitin, Kenney, M. Cristina
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053329/
https://ncbi.nlm.nih.gov/pubmed/24919117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099003
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