Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)

[Image: see text] Oligonucleotides modified with conformationally restricted nucleotides such as locked nucleic acid (LNA) monomers are used extensively in molecular biology and medicinal chemistry to modulate gene expression at the RNA level. Major efforts have been devoted to the design of LNA der...

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Main Authors: Kumar, Pawan, Østergaard, Michael E., Baral, Bharat, Anderson, Brooke A., Guenther, Dale C., Kaura, Mamta, Raible, Daniel J., Sharma, Pawan K., Hrdlicka, Patrick J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4049237/
https://ncbi.nlm.nih.gov/pubmed/24825249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo500614a
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