Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

The success of adoptively transferred tumor-directed T cells requires them to survive and expand in vivo. Most tumors, however, employ immune evasion mechanisms, including the production of inhibitory cytokines that limit in vivo T-cell persistence and effector function. To protect tumor-directed T...

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Autors principals: Leen, Ann M, Sukumaran, Sujita, Watanabe, Norihiro, Mohammed, Somala, Keirnan, Jacqueline, Yanagisawa, Ryu, Anurathapan, Usanarat, Rendon, David, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Vera, Juan F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048899/
https://ncbi.nlm.nih.gov/pubmed/24732709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.47
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