Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer

The adoptive transfer of T cells redirected to tumor-associated antigens via transgenic expression of chimeric antigen receptors (CARs) has produced tumor responses, even in patients with refractory diseases. To target pancreatic cancer, we generated CAR T cells directed against prostate stem cell a...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Mohammed, Somala, Sukumaran, Sujita, Bajgain, Pradip, Watanabe, Norihiro, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Fisher, William E., Leen, Ann M., Vera, Juan F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363304/
https://ncbi.nlm.nih.gov/pubmed/28129119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.016
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