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Enhancing the potency and specificity of engineered T cells for cancer treatment
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has produced tumor responses even in patients with refractory diseases. However, the paucity of antigens that are tumor selective has resulted, on occasion, in “on-target, off-tumor” toxicities. To address this issue, we devel...
Uloženo v:
| Vydáno v: | Cancer Discov |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428579/ https://ncbi.nlm.nih.gov/pubmed/29880586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1298 |
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