Fine-tuning the CAR spacer improves T-cell potency

The adoptive transfer of genetically engineered T cells expressing chimeric antigen receptors (CARs) has emerged as a transformative cancer therapy with curative potential, precipitating a wave of preclinical and clinical studies in academic centers and the private sector. Indeed, significant effort...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Autores principales: Watanabe, Norihiro, Bajgain, Pradip, Sukumaran, Sujita, Ansari, Salma, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Leen, Ann M., Vera, Juan F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214260/
https://ncbi.nlm.nih.gov/pubmed/28180032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1253656
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