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Enhancing the potency and specificity of engineered T cells for cancer treatment
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has produced tumor responses even in patients with refractory diseases. However, the paucity of antigens that are tumor selective has resulted, on occasion, in “on-target, off-tumor” toxicities. To address this issue, we devel...
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| Publicado en: | Cancer Discov |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6428579/ https://ncbi.nlm.nih.gov/pubmed/29880586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1298 |
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