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Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues

The nucleotide substrate specificity of yeast poly(A) polymerase (yPAP) was examined with various ATP analogues of clinical relevance. The triphosphate derivatives of cladribine (2-Cl-dATP), clofarabine (Cl-F-ara-ATP), fludarabine (F-ara-ATP), and related derivatives were incubated with yPAP and (32...

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Autors principals: Chen, Lisa S., Plunkett, William, Gandhi, Varsha
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048126/
https://ncbi.nlm.nih.gov/pubmed/18433867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.03.010
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