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Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues

The nucleotide substrate specificity of yeast poly(A) polymerase (yPAP) was examined with various ATP analogues of clinical relevance. The triphosphate derivatives of cladribine (2-Cl-dATP), clofarabine (Cl-F-ara-ATP), fludarabine (F-ara-ATP), and related derivatives were incubated with yPAP and (32...

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Hlavní autoři: Chen, Lisa S., Plunkett, William, Gandhi, Varsha
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048126/
https://ncbi.nlm.nih.gov/pubmed/18433867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2008.03.010
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