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Inhibition of ATP Synthase by Chlorinated Adenosine Analogue
8-Chloroadenosine (8-Cl-Ado) is a ribonucleoside analogue that is currently in clinical trial for chronic lymphocytic leukemia. Based on the decline in cellular ATP pool following 8-Cl-Ado treatment, we hypothesized that 8-Cl-ADP and 8-Cl-ATP may interfere with ATP synthase, a key enzyme in ATP prod...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2763632/ https://ncbi.nlm.nih.gov/pubmed/19477165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.05.019 |
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