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Chlorinated adenosine analogue induces AMPK and autophagy in chronic lymphocytic leukaemia cells during therapy
8-chloro-adenosine (8-Cl-Ado) is currently in phase-I clinical trials for acute myeloid leukaemia and chronic lymphocytic leukaemia (CLL). Treatment with 8-Cl-Ado has been shown to diminish ATP levels. We hypothesized that AMP-activated protein kinase (AMPK) signalling would be initiated in these ce...
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| Publicado no: | Br J Haematol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5638689/ https://ncbi.nlm.nih.gov/pubmed/28737232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.14859 |
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