Cell death of bioenergetically compromised and transcriptionally challenged CLL lymphocytes by chlorinated ATP

Myeloid cell leukemia-1 (MCL-1) acts as a key survival factor for chronic lymphocytic leukemia (CLL) cells. In addition, dissipation of cellular bioenergy may impose a lethal effect on these quiescent cells. Previously, in multiple myeloma cell lines we demonstrated that halogenated adenosine (8-Cl-...

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Detalhes bibliográficos
Main Authors: Balakrishnan, Kumudha, Stellrecht, Christine M., Genini, Davide, Ayres, Mary, Wierda, William G., Keating, Michael J., Leoni, Lorenzo M., Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895042/
https://ncbi.nlm.nih.gov/pubmed/15718423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-05-1699
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