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Chain Termination and Inhibition of Mammalian Poly(A) Polymerase by modified ATP analogues
We report the inhibition of mammalian polyadenylation by the triphosphate derivatives of adenosine analogues, 8-chloroadenosine (8-Cl-Ado) and 8-aminoadenosine (8-amino-Ado), which are under preclinical and clinical investigations for the treatment of hematological malignancies. The nucleotide subst...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812641/ https://ncbi.nlm.nih.gov/pubmed/19814999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.09.028 |
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