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Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function

The addition of the poly(A) tail to the ends of eukaryotic mRNAs is catalyzed by poly(A) polymerase (PAP). PAP activity is known to be highly regulated, for example, by alternative splicing and phosphorylation. In this study we show that the small ubiquitin-like modifier (SUMO) plays multiple roles...

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Autori principali: Vethantham, Vasupradha, Rao, Nishta, Manley, James L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2238671/
https://ncbi.nlm.nih.gov/pubmed/18281463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1628208
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