Chain Termination and Inhibition of Mammalian Poly(A) Polymerase by modified ATP analogues

We report the inhibition of mammalian polyadenylation by the triphosphate derivatives of adenosine analogues, 8-chloroadenosine (8-Cl-Ado) and 8-aminoadenosine (8-amino-Ado), which are under preclinical and clinical investigations for the treatment of hematological malignancies. The nucleotide subst...

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Main Authors: Chen, Lisa S., Du-Cuny, Lei, Vethantham, Vasupradha, Hawke, David H., Manley, James L., Zhang, Shuxing, Gandhi, Varsha
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812641/
https://ncbi.nlm.nih.gov/pubmed/19814999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.09.028
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