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Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death
Flavopiridol is active against chronic lymphocytic leukemia (CLL) cells in vitro and in the treatment of advanced stage disease, but the mechanisms of these actions remain unclear. Originally developed as a general cyclin-dependent kinase inhibitor, flavopiridol is a potent transcriptional suppresso...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895272/ https://ncbi.nlm.nih.gov/pubmed/15972445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1678 |
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