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Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death

Flavopiridol is active against chronic lymphocytic leukemia (CLL) cells in vitro and in the treatment of advanced stage disease, but the mechanisms of these actions remain unclear. Originally developed as a general cyclin-dependent kinase inhibitor, flavopiridol is a potent transcriptional suppresso...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Chen, Rong, Keating, Michael J., Gandhi, Varsha, Plunkett, William
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society of Hematology 2005
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895272/
https://ncbi.nlm.nih.gov/pubmed/15972445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1678
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