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Carfilzomib triggers cell death in chronic lymphocytic leukemia by inducing proapoptotic and endoplasmic reticulum stress responses

PURPOSE: Carfilzomib, while active in B-cell neoplasms displayed heterogeneous response in chronic lymphocytic leukemia (CLL) samples from patients and showed interpatient variability to carfilzomib-induced cell death. To understand this variability and predict patients that would respond to carfilz...

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Pubblicato in:Clin Cancer Res
Autori principali: Lamothe, Betty, Wierda, William G., Keating, Michael J., Gandhi, Varsha
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5118040/
https://ncbi.nlm.nih.gov/pubmed/27026200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2522
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