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Selective Overexpression of Dopamine D3 Receptors in the Striatum Disrupts Motivation but not Cognition

BACKGROUND: Evidence indicating an increase in dopamine D2 receptor (D2R) density and occupancy in patients with schizophrenia comes from positron emission tomography studies using ligands that bind both D2Rs and dopamine D3 receptors (D3Rs), questioning the role of D3Rs in the pathophysiology of th...

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Bibliografiske detaljer
Main Authors: Simpson, Eleanor H., Winiger, Vanessa, Biezonski, Dominik K., Haq, Iram, Kandel, Eric R., Kellendonk, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047204/
https://ncbi.nlm.nih.gov/pubmed/24387821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.11.023
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