Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer’s disease(2, 3) and is associated with Down’s syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage(3). Neurovascular dysfunction is present...

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Main Authors: BELL, R. D., WINKLER, E. A., SINGH, I., SAGARE, A. P., DEANE, R., WU, Z., HOLTZMAN, D. M., BETSHOLTZ, C., ARMULIK, A., SALLSTROM, J., BERK, B. C., ZLOKOVIC, B. V.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047116/
https://ncbi.nlm.nih.gov/pubmed/22622580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11087
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