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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer’s disease(2, 3) and is associated with Down’s syndrome dementia and poor neurological outcome after traumatic brain injury and haemorrhage(3). Neurovascular dysfunction is present...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4047116/ https://ncbi.nlm.nih.gov/pubmed/22622580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11087 |
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