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A Loss of Function Analysis of Host Factors Influencing Vaccinia virus Replication by RNA Interference

Vaccinia virus (VACV) is a large, cytoplasmic, double-stranded DNA virus that requires complex interactions with host proteins in order to replicate. To explore these interactions a functional high throughput small interfering RNA (siRNA) screen targeting 6719 druggable cellular genes was undertaken...

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Detalhes bibliográficos
Main Authors: Beard, Philippa M., Griffiths, Samantha J., Gonzalez, Orland, Haga, Ismar R., Pechenick Jowers, Tali, Reynolds, Danielle K., Wildenhain, Jan, Tekotte, Hille, Auer, Manfred, Tyers, Mike, Ghazal, Peter, Zimmer, Ralf, Haas, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4047015/
https://ncbi.nlm.nih.gov/pubmed/24901222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098431
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