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PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila

Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated at Ser65 within the ubiquitin-like domai...

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Bibliografiske detaljer
Main Authors: Shiba-Fukushima, Kahori, Inoshita, Tsuyoshi, Hattori, Nobutaka, Imai, Yuzuru
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046931/
https://ncbi.nlm.nih.gov/pubmed/24901221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004391
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