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A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels

Altered cellular bioenergetics and mitochondrial function are major features of several diseases including cancer, diabetes, and neurodegenerative disorders. Given this important link to human health, we sought to define proteins within mitochondria that are critical for maintaining homeostatic ATP...

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Detalhes bibliográficos
Main Authors: Lanning, Nathan J., Looyenga, Brendan D., Kauffman, Audra L., Niemi, Natalie M., Sudderth, Jessica, DeBerardinis, Ralph J., MacKeigan, Jeffrey P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046887/
https://ncbi.nlm.nih.gov/pubmed/24767988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.03.065
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