STAT3 Is Activated by JAK2 Independent of Key Oncogenic Driver Mutations in Non-Small Cell Lung Carcinoma

Constitutive activation of STAT3 is a common feature in many solid tumors including non-small cell lung carcinoma (NSCLC). While activation of STAT3 is commonly achieved by somatic mutations to JAK2 in hematologic malignancies, similar mutations are not often found in solid tumors. Previous work has...

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Main Authors: Looyenga, Brendan D., Hutchings, Danielle, Cherni, Irene, Kingsley, Chris, Weiss, Glen J., MacKeigan, Jeffrey P.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271110/
https://ncbi.nlm.nih.gov/pubmed/22319590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030820
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