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Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases

[Image: see text] The role of protein dynamics in the reaction catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) has been examined by enzyme isotope substitution ((15)N, (13)C, (2)H). In contrast to all other enzyme reactions investigated previously, includi...

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Bibliografische gegevens
Hoofdauteurs: Luk, Louis Y. P., Loveridge, E. Joel, Allemann, Rudolf K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2014
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046772/
https://ncbi.nlm.nih.gov/pubmed/24779446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502673h
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