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Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
[Image: see text] The role of protein dynamics in the reaction catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) has been examined by enzyme isotope substitution ((15)N, (13)C, (2)H). In contrast to all other enzyme reactions investigated previously, includi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046772/ https://ncbi.nlm.nih.gov/pubmed/24779446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502673h |
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