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Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
[Image: see text] The role of protein dynamics in the reaction catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) has been examined by enzyme isotope substitution ((15)N, (13)C, (2)H). In contrast to all other enzyme reactions investigated previously, includi...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2014
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4046772/ https://ncbi.nlm.nih.gov/pubmed/24779446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502673h |
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