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Pot1a Prevents Telomere Dysfunction and ATM-Dependent Neuronal Loss

Genome stability is essential for neural development and the prevention of neurological disease. Here we determined how DNA damage signaling from dysfunctional telomeres affects neurogenesis. We found that telomere uncapping by Pot1a inactivation resulted in an Atm-dependent loss of cerebellar inter...

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Detalhes bibliográficos
Main Authors: Lee, Youngsoo, Brown, Eric J., Chang, Sandy, McKinnon, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4044246/
https://ncbi.nlm.nih.gov/pubmed/24899707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4245-13.2014
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