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Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

Ataxia telangiectasia results from mutations of ATM and is characterized by severe neurodegeneration and defective responses to DNA damage. Inactivation of certain DNA repair genes such as DNA ligase IV results in massive neuronal apoptosis and embryonic lethality in the mouse, indicating the occurr...

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Hlavní autoři: Lee, Youngsoo, Barnes, Deborah E., Lindahl, Tomas, McKinnon, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2000
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC316986/
https://ncbi.nlm.nih.gov/pubmed/11040211
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