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Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
The rapid proliferation of progenitors during neurogenesis requires a stringent genomic maintenance program to ensure transmission of genetic fidelity. However the essential factors that govern neural progenitor genome integrity are unknown. Here we report that conditional inactivation of mouse TopB...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404252/ https://ncbi.nlm.nih.gov/pubmed/22522401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3097 |
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