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Development of Selective Inhibitors for Human Aldehyde Dehydrogenase 3A1 (ALDH3A1) for the Enhancement of Cyclophosphamide Cytotoxicity

Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemo-resistance by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues such as mafosfamide (MF), ifosfamide (IFM), 4-hydroperoxycycl...

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Bibliografiske detaljer
Main Authors: Parajuli, Bibek, Georgiadis, Taxiarchis M., Fishel, Melissa L., Hurley, Thomas D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4043872/
https://ncbi.nlm.nih.gov/pubmed/24677340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300625
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