Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

Human aldehyde dehydrogenases (ALDHs) comprise a family of 17 homologous enzymes that metabolize different biogenic and exogenic aldehydes. To date, there are relatively few general ALDH inhibitors that can be used to probe the contribution of this class of enzymes to particular metabolic pathways....

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Bibliographische Detailangaben
Hauptverfasser: Khanna, May, Chen, Che-Hong, Kimble-Hill, Ann, Parajuli, Bibek, Perez-Miller, Samantha, Baskaran, Sulochanadevi, Kim, Jeewon, Dria, Karl, Vasiliou, Vasilis, Mochly-Rosen, Daria, Hurley, Thomas D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234859/
https://ncbi.nlm.nih.gov/pubmed/22021038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293597
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