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Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant
In approximately one billion people, a point mutation inactivates a key detoxifying enzyme, aldehyde dehydrogenase (ALDH2). This mitochondrial enzyme metabolizes toxic biogenic and environmental aldehydes, including the endogenously produced 4-hydroxynonenal (4HNE) and the environmental pollutant, a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857674/ https://ncbi.nlm.nih.gov/pubmed/20062057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1737 |
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