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Functional and biochemical dissection of the structure-specific nuclease ARTEMIS
During V(D)J recombination, the RAG1 and RAG2 proteins form a complex and initiate the process of rearrangement by cleaving between the coding and signal segments and generating hairpins at the coding ends. Prior to ligation of the coding ends by DNA ligase IV/XRCC4, these hairpins are opened by the...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC404326/ https://ncbi.nlm.nih.gov/pubmed/15071507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600206 |
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