CtIP-mediated resection is essential for viability and can operate independently of BRCA1

Homologous recombination (HR) is initiated by DNA end resection, a process in which stretches of single-strand DNA (ssDNA) are generated and used for homology search. Factors implicated in resection include nucleases MRE11, EXO1, and DNA2, which process DNA ends into 3′ ssDNA overhangs; helicases su...

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Detalles Bibliográficos
Main Authors: Polato, Federica, Callen, Elsa, Wong, Nancy, Faryabi, Robert, Bunting, Samuel, Chen, Hua-Tang, Kozak, Marina, Kruhlak, Michael J., Reczek, Colleen R., Lee, Wen-Hwa, Ludwig, Thomas, Baer, Richard, Feigenbaum, Lionel, Jackson, Stephen, Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2014
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042650/
https://ncbi.nlm.nih.gov/pubmed/24842372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131939
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