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Structures and mechanism for the design of highly potent glucocorticoids
The evolution of glucocorticoid drugs was driven by the demand of lowering the unwanted side effects, while keeping the beneficial anti-inflammatory effects. Potency is an important aspect of this evolution as many undesirable side effects are associated with use of high-dose glucocorticoids. The si...
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Main Authors: | , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042175/ https://ncbi.nlm.nih.gov/pubmed/24763108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.52 |
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