Development of highly potent glucocorticoids for steroid-resistant severe asthma

Clinical application of inhaled glucocorticoids (GCs) has been hampered in the case of steroid-resistant severe asthma. To overcome this limitation, we have developed a series of highly potent GCs, including VSGC12, VSG158, and VSG159 based on the structural insight into the glucocorticoid receptor...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: He, Yuanzheng, Shi, Jingjing, Nguyen, Quang Tam, You, Erli, Liu, Hongbo, Ren, Xin, Wu, Zhongshan, Li, Jianshuang, Qiu, Wenli, Khoo, Sok Kean, Yang, Tao, Yi, Wei, Sun, Feng, Xi, Zhijian, Huang, Xiaozhu, Melcher, Karsten, Min, Booki, Xu, H. Eric
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6452690/
https://ncbi.nlm.nih.gov/pubmed/30894497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816734116
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