Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism

The intestinal epithelium is subjected to various types of mechanical stress. In this study, we investigated the impact of cyclic stretch on tight junction and adherens junction integrity in Caco-2 cell monolayers. Stretch for 2 h resulted in a dramatic modulation of tight junction protein distribut...

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Main Authors: Samak, Geetha, Gangwar, Ruchika, Crosby, Lynn M., Desai, Leena P., Wilhelm, Kristina, Waters, Christopher M., Rao, RadhaKrishna
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2014
Teme:
Mucosal Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042113/
https://ncbi.nlm.nih.gov/pubmed/24722904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00396.2013
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