Cyclic stretch disrupts apical junctional complexes in Caco-2 cell monolayers by a JNK-2-, c-Src-, and MLCK-dependent mechanism

The intestinal epithelium is subjected to various types of mechanical stress. In this study, we investigated the impact of cyclic stretch on tight junction and adherens junction integrity in Caco-2 cell monolayers. Stretch for 2 h resulted in a dramatic modulation of tight junction protein distribut...

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Detalhes bibliográficos
Main Authors: Samak, Geetha, Gangwar, Ruchika, Crosby, Lynn M., Desai, Leena P., Wilhelm, Kristina, Waters, Christopher M., Rao, RadhaKrishna
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Mucosal Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042113/
https://ncbi.nlm.nih.gov/pubmed/24722904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00396.2013
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