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Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation
Internal anal sphincter (IAS) tone plays an important role in rectoanal incontinence (RI). IAS tone may be compromised during aging, leading to RI in certain patients. We examined the influence of oxidative stress in the aging-associated decrease in IAS tone (AADI). Using adult (4–6 mo old) and agin...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4042111/ https://ncbi.nlm.nih.gov/pubmed/24742984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00087.2014 |
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