Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation

Internal anal sphincter (IAS) tone plays an important role in rectoanal incontinence (RI). IAS tone may be compromised during aging, leading to RI in certain patients. We examined the influence of oxidative stress in the aging-associated decrease in IAS tone (AADI). Using adult (4–6 mo old) and agin...

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Detaylı Bibliyografya
Asıl Yazarlar: Singh, Jagmohan, Kumar, Sumit, Krishna, Chadalavada Vijay, Rattan, Satish
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2014
Konular:
Hormones and Signaling
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042111/
https://ncbi.nlm.nih.gov/pubmed/24742984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00087.2014
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