3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation

RhoA prenylation may play an important step in the translocation of RhoA in the basal internal anal sphincter (IAS) smooth muscle tone. Statins inhibit downstream posttranslational RhoA prenylation by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition (HMGCRI). The role of statins...

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Hlavní autor: Rattan, Satish
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
Témata:
Hormones and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774330/
https://ncbi.nlm.nih.gov/pubmed/20378830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00034.2010
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