3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation

RhoA prenylation may play an important step in the translocation of RhoA in the basal internal anal sphincter (IAS) smooth muscle tone. Statins inhibit downstream posttranslational RhoA prenylation by 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibition (HMGCRI). The role of statins...

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Bibliografiset tiedot
Päätekijä: Rattan, Satish
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2010
Aiheet:
Hormones and Signaling
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774330/
https://ncbi.nlm.nih.gov/pubmed/20378830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00034.2010
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