Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells

Studies were performed to determine the unknown status of PKC and RhoA/ROCK in the phorbol 12,13-dibutyrate (PDBu)-stimulated state in the human internal anal sphincter (IAS) smooth muscle cells (SMCs). We determined the effects of PDBu (10(−7) M), the PKC activator, on PKCα and RhoA and ROCK II tra...

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Bibliographic Details
Main Authors: Singh, Jagmohan, Maxwell, Pinckney J., Rattan, Satish
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
Subjects:
Hormones and Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154599/
https://ncbi.nlm.nih.gov/pubmed/21566015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00084.2011
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