Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53

BACKGROUND: Survivin, a member of the inhibitor of apoptosis (IAP) gene family, has a dual role in mitosis and in apoptosis. It is abundantly expressed in every human tumor, compared with normal tissues. During mitosis Survivin assembles with the chromosomal passenger complex and regulates chromosom...

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Dades bibliogràfiques
Autors principals: Wiedemuth, Ralf, Klink, Barbara, Töpfer, Katrin, Schröck, Evelin, Schackert, Gabriele, Tatsuka, Masaaki, Temme, Achim
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041913/
https://ncbi.nlm.nih.gov/pubmed/24886358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-107
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