Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ). Homologous recombination repair (HRR) is functional during the S- and G2-phases, when a si...

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Bibliografische gegevens
Hoofdauteurs: Soni, Aashish, Siemann, Maria, Grabos, Martha, Murmann, Tamara, Pantelias, Gabriel E., Iliakis, George
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2014
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041464/
https://ncbi.nlm.nih.gov/pubmed/24748665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku298
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