Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

RATIONALE: Stimulation of β3-adrenoreceptors (β3-AR) blunts contractility and improves chronic left ventricular function in hypertrophied and failing hearts in a neuronal nitric oxide synthase (nNOS) dependent manner. nNOS can be regulated by post-translational modification of stimulatory phosphoryl...

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Autors principals: Watts, Vabren L., Sepulveda, Fernando M., Cingolani, Oscar H., Ho, Alice S., Niu, Xiaolin, Kim, Rosa, Miller, Karen L., Vandegaer, Koenraad, Bedja, Djahida, Gabrielson, Kathleen L., Rameau, Gerald, O'Rourke, Brian, Kass, David A., Barouch, Lili A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4041152/
https://ncbi.nlm.nih.gov/pubmed/23643588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.04.025
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