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Immunoglobulin G1 Fc domain motions: implications for Fc engineering
The fragment crystallizable (Fc) region links the key pathogen identification and destruction properties of immunoglobulin G(IgG). Pathogen opsonization positions Fcs to activate pro-inflammatory Fcγ receptors (FcγRs) on immune cells. The cellular response and committal to a damaging, though protect...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041121/ https://ncbi.nlm.nih.gov/pubmed/24522230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.01.011 |
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